The most common causes of pain in the ball of the foot after running are inappropriate shoes, plantar fasciitis, fatigue fracture, gout and so on. 1. Inappropriate shoes: If the patient’s shoes are too hard, they may repeatedly wear out the feet during running, causing pain in the palms of the feet after running, and the patient should replace the shoes with loose and comfortable ones. 2. Plantar fasciitis: this is a kind of aseptic inflammation, if the patient runs for a long time, the overloaded force of the plantar fascia can cause pain in the ball of the foot. 3. Fatigue fracture: if the patient runs too strenuously, muscle fatigue, it will weaken the buffer effect on the bones, continuous and repeated stress on the bones, it is easy to fatigue fracture, which will cause the patient’s foot pain. 4. Gout: If the patient has gout stones, the body uric acid level is not well controlled, may also induce acute attacks of gouty arthritis, redness, swelling and pain in the palms of the feet after running. Caused by running pain in the palms of the feet of more reasons, if the rest does not relieve, it is recommended to go to the hospital in time to identify the cause of the disease, by the doctor targeted treatment.