If you are taking a first-line antihypertensive drug and your blood pressure is controlled smoothly without significant side effects, you do not need to change it frequently. If the following situations occur, it is necessary to consider adjusting the medication: First, the blood pressure control is not satisfactory. If you monitor your blood pressure and the goal of lowering your blood pressure is not achieved, or if there is a wide range of blood pressure fluctuations, this is the time to consider adjusting your antihypertensive medication. The second situation is the emergence of serious side effects. Generally speaking antihypertensive drugs are very safe, but some side effects can occur. For example, often taken captopril, benadryl, prilosec class of antihypertensive drugs, its side effect is dry cough. If you take Benadryl for a long time, the emergence of severe cough for more than two weeks still can not be relieved, can not be tolerated, consider adjusting the antihypertensive drugs. Third, the kind of situation is to find some new disease, for example, did not suffer from coronary heart disease, did not suffer from heart failure, did not have chronic renal insufficiency and so on, and now the new discovery of these problems, taking the antihypertensive drugs need to be adjusted. It should be reminded that any adjustment of medication needs to be done under the guidance of a doctor. Patients should never blindly reduce, increase, or even change medications on their own.