If you are taking a first-line antihypertensive drug and your blood pressure is controlled smoothly without significant side effects, you do not need to change it frequently. If the following situations occur, it is necessary to consider adjusting the medication: First, the blood pressure control is not satisfactory. If the blood pressure is monitored and the goal of lowering blood pressure is not achieved, or there is a wide range of blood pressure fluctuations, it is time to consider adjusting the antihypertensive medication. Second, is the emergence of serious side effects. Generally speaking, antihypertensive drugs are very safe, but some side effects can occur. For example, often take captopril, benadryl, prilosec class of antihypertensive drugs, its side effect is dry cough. If a long time to take Benadryl class of drugs, the emergence of severe cough for more than two weeks still can not be relieved, can not be tolerated, consider adjusting the antihypertensive drugs. Thirdly, it is found that some new diseases, such as no previous coronary heart disease, no heart failure, no chronic renal insufficiency and so on, and now the new discovery of these problems, taking antihypertensive drugs need to be adjusted. It should be reminded that any adjustment of medication needs to be done under the guidance of a doctor. Patients should never blindly reduce, increase, or even change medications on their own.