Patient: I. Situation: the male side of the three-dimensional yang liver function is normal DNA negative virus can not be detected, the female side of the antibody titer big 1000. 2, questions: Professor Zhao Lian San believes that: “the theory of the existence of father-to-child transmission, and at present, some scholars completely negate the actual existence of father-to-child transmission, while some scholars believe that the risk of father-to-child transmission is quite high”. . I have also seen relevant experts such as Luo Anti-sian, Cheng Jun, Cai Haodong, etc. denying the vertical transmission from father to child or considering it negligible; and I have also seen information that says it is as high as 80% or 20%. Therefore, I would like to ask you, what is the chance of vertical transmission from father to child in the case of a male with normal liver function and DNA negative virus, and a female with antibody titer greater than 1,000? Hu Airong, Department of Hepatology, Ningbo Infectious Diseases Hospital: I totally agree with Luo Anti Xian, Cheng Jun, Cai Haodong and other denial of vertical transmission from father to child, because the transmission of hepatitis B is through the virus, not the DNA, and the detection of the hepatitis B virus DNA from semen alone does not mean that the hepatitis B virus is transmitted through semen, and the same reasoning is that the transmission of the female breast milk is also not recognized.