Parkinson’s disease, a chronic progressive disease of the elderly, patients’ symptoms will gradually worsen with the development of the disease. When Parkinson’s disease develops into middle or late stage, patients often develop complications, such as autonomic dysfunction, psychological disorder, motor difficulty, infection and limb joint contracture and deformity, which seriously affects the quality of life and health of patients. According to the patient’s condition, doctors will evaluate the progression of Parkinson’s disease. The Hoehn-Yahr staging is mainly used in the clinic, which divides the progression of Parkinson’s disease into five stages. Stage I Only unilateral lesions, unilateral hand tremor, foot tremor or stiffness, walking not as sharp as usual, unsteady in holding things. Since it does not have a great impact on life, it is often easy to be ignored by patients and their families. If timely treatment is provided during this period, there is a great hope that the patient’s symptoms will be completely controlled! Stage II Mild bilateral lesions, from unilateral lesions to bilateral, hands shaking, or even the whole body shaking, stiffness aggravated, buttons, chopsticks and other daily activities become difficult to button, walking effort, poor sense of balance. Stage III Bilateral lesions with early balance disorders, difficulty in lifting legs, legs like heavy sandbags, walking small steps, shuffling steps and leaning forward, easy to fall. He can’t hold the bowl steadily for meals and needs help from family members in daily activities such as turning over at night and bathing. Stage IV Severe lesions requiring a lot of help, often involuntary drooling, difficulty in swallowing, slow eating. Speech is slurred, and the voice is so small that bystanders have to come close to hear clearly. Dull expression, mask face appears, facial muscles also become more and more stiff, no expression on the face, seldom blinking, and eye movements are reduced. Movement is difficult and daily life cannot be taken care of by family members. Stage V Completely unable to take care of themselves in daily life, confined to bed or wheelchair. Confined to bed or wheelchair unless assisted by family members. Some patients are only confined to bed for a long period of time, cannot stand up by themselves after sitting down, cannot turn over by themselves after being confined to bed, and cannot take care of themselves at all in daily life. Early Parkinson’s disease can consider drug treatment, that is, after the onset of the disease to about four or five years of time, you can get very good therapeutic effect, this period of time is called the “honeymoon period” of the use of drugs, and do not need surgical treatment. However, when the disease reaches a certain stage, the effect of medication is not obvious, and even if the dosage of medication is increased, it is not possible to further improve the symptoms, and there will also be drug side effects and complications, such as anisotropy, on-off phenomenon, end-of-dose phenomenon, and so on. Through surgical treatment, a better therapeutic effect can be obtained and the dosage of medication can be reduced. Deep Brain Stimulation (DBS) Implanting biological electrodes into the patient’s cranium and using an electrical pulse generator to stimulate certain specific neural nuclei in the deep part of the brain, correcting the abnormal electrical circuits of the brain and alleviating the related neurological symptoms, so as to achieve the purpose of improving the clinical symptoms of Parkinson’s disease patients. How to choose the best time for surgery for Parkinson’s disease patients Surgical treatment for Parkinson’s disease patients also involves the issue of the time window for surgery, i.e., what time to choose for surgery to maximize the most desirable results. Parkinson’s disease itself is a chronic progressive disease, and the timing of surgery is particularly important, as timely intervention can buy patients 20-30 years. Early surgical implantation of a pacemaker for Parkinson’s disease improves quality of life and motor function, and greatly reduces drug-induced motor complications. Age and disease duration are important factors in choosing between pharmacologic or surgical treatment, with younger patients having more room for improvement in quality of life and symptoms, fewer complications, and slower deterioration of mid-axis symptoms. The best time to consider undergoing brain pacemaker implantation is when patients with Parkinson’s disease experience a decline in medication efficacy or motor fluctuations and anisotropy.