Isotonic Hypohydration Inputting large amounts of isotonic saline may result in hyperchloric acidosis. In isotonic dehydration, the main treatment used is compounded sodium chloride solution. In isotonic dehydration, the loss of water is comparable to the loss of sodium. If large amounts of isotonic saline are supplemented, the sodium ion level can be maintained in the normal range, but the concentration of chloride ions will be much higher than the normal concentration. At the same time, due to the loss of sodium ions, resulting in a decrease in renal tubular hydrogen-sodium exchange and an increase in reabsorption of chloride ions, over time the formation of hyperchloremic acidosis. If elevated blood chloride occurs after isotonic dehydration with input of large amounts of isotonic saline, it should be corrected immediately without delay to avoid adverse consequences.