Glycolysis 125 before lung adenocarcinoma surgery is normal, but it is elevated after surgery, which is abnormal phenomenon and may be caused by inflammation, tumor recurrence and metastasis. Glycosyl 125, also known as CA125, is a broad-spectrum tumor marker, mainly used for screening of ovarian cancer, etc. If the index is normal before lung adenocarcinoma surgery but increases after surgery, it may be caused by ovarian metastasis of the tumor or postoperative complication of pelvic inflammation and vaginitis, which is an abnormal phenomenon. After encountering lung adenocarcinoma with normal Glycosyl 125 index before surgery but increased after surgery, it is necessary to improve abdominal CT, blood routine and pathological tissue biopsy in time to clarify the specific causes of the disease. If it is caused by tumor metastasis, surgery, radiotherapy and other treatments should be taken according to the number and size of tumor; if it is caused by pelvic inflammation and other diseases, doxycycline, levofloxacin and other treatments should be used. The elevation of CA125 after lung pancreatic cancer surgery should be taken seriously, and it is recommended to screen the causes of the disease under the guidance of doctors and take targeted treatment in time to avoid delaying the condition.