Nimesulide granules are mainly non-steroidal anti-inflammatory drugs with anti-inflammatory, analgesic and antipyretic effects, mainly used for chronic arthritis, pain and inflammation after surgery and acute trauma, inflammation of the ear, nose and throat, as well as dysmenorrhea and fever caused by upper respiratory tract infections, etc. They are more commonly used clinically, and children can also apply the above drugs, but there will be some adverse side effects, such as heartburn, nausea, stomach pain etc. In addition, there are other adverse side effects, including dizziness, drowsiness, gastric ulcers and bleeding, which must be given proper attention. Apart from Nimesulide, there are many clinically available drugs to choose from, and it is important to try to circumvent it to choose the right drug according to the different side effects so that the patient can get the maximum benefit.