It is not normal for mupirocin ointment to itch when applied, consider an adverse reaction. Mupirocin ointment is an antibiotic ointment that is mainly used for skin infections caused by gram-positive cocci, and it can be used to prevent infections when there is a small superficial trauma to the skin. Mupirocin ointment may appear local burning sensation or itching sensation and other adverse reactions, usually do not need to stop the drug, after a period of time the symptoms can disappear, but if there is a serious skin allergies, such as swelling of the rash, redness, flaking, etc., you should stop using the medication immediately, and go to the hospital in time to see a doctor. It should be noted that people who are allergic to mupirocin or other ointments containing polyethylene glycol can not be used, in addition, if the symptoms do not improve or worsen after a course of treatment, you should consult a doctor in a timely manner, under the guidance of the doctor to regulate the treatment, can not be used for the eyes, the nose, the mouth and other mucous membrane parts. It is recommended to use the medication under the guidance of a doctor, not blindly self-medication, in order to avoid adverse reactions.