Migraine and trigeminal neuralgia are two very different diseases, as follows: 1. Migraine is a kind of neurovascular pain, common in women, often occurring on the temporal side, presenting throbbing headache. Common triggers are tension, exertion, menstrual disorders, and some patients can be caused by diet. An easy way to identify migraine is to compress the superficial temporal artery, and the symptoms are relieved; 2. Trigeminal neuralgia belongs to another disease, which is divided into primary trigeminal neuralgia and secondary trigeminal neuralgia. Trigeminal neuralgia is characterized by episodic, transient, lacerating, slashing, pinprick, and discharging pains, and the range is in the region of trigeminal innervation, which is commonly found in the face. Primary trigeminal neuralgia is usually thought to be caused by blood vessels compressing the trigeminal nerve and can be treated surgically. Secondary trigeminal neuralgia is caused by a tumor or other lesion and requires treatment of the cause. Therefore, although migraine and trigeminal neuralgia are both common clinical diseases, they have different mechanisms and treatments, and need to be carefully analyzed and treated separately.