Sartan antihypertensive drugs commonly used in clinical practice include valsartan and chlorosartan, etc. Due to individual variability in drug tolerance, it is impossible to accurately determine which drug does not cause headaches. Valsartan, chlorosartan, timosartan and other drugs belong to the angiotensin II receptor antagonist, clinically applicable to the treatment of primary hypertension. Adverse reactions such as rash, diarrhea, and headache may occur during administration. Due to individual variability, there is no complete guarantee that there will be no headache sartans antihypertensive drugs can not accurately determine whether it will cause headache, when headache and other adverse reactions occur in the process of medication, it is recommended to go to the hospital in a timely manner, drug allergy is prohibited.