The soles of the feet are rotten with many small holes and stinky, consider the following two possibilities: 1. Vulgar keratosis: mainly caused by bacterial infection, can be treated with topical fusidic acid cream or compound polymyxin B ointment for application. Usually occurs in people with sweaty feet, and wear too tight, too closed shoes, resulting in local humidity, hot and stuffy environment triggered. The above mentioned causes can be avoided to achieve a better treatment. 2. Tinea pedis secondary infection: Tinea pedis is mainly caused by fungal infection and bacterial co-infection due to scratching, which requires oral antibiotic amoxicillin capsules and topical polymyxin B ointment for anti-bacterial infection. After the anti-bacterial infection has reached its effect, then apply cotrimoxazole ointment for antifungal treatment.