The supraclavicular lymph nodes are important lymph nodes in the body, usually collecting lymphatic return fluid from the upper extremities, head, face and neck. If there is hyperplasia and enlargement, it may be microbial infection, lymph node’s own disease or cancer metastasis. 1. Microbial infections: when various infections occur in the upper limbs, head, face and neck, the lymph nodes may become enlarged and need to be treated according to the infection. 2. Lymph node diseases: leukemia, lymphoma and other lymph node diseases can cause the lymph nodes to increase in size, and timely pathological biopsy, symptomatic treatment or radiotherapy, chemotherapy and targeted therapy, bone marrow transplantation and other treatments should be carried out. 3. Metastatic foci of cancer: metastatic foci of lung cancer, thyroid cancer, laryngeal cancer, breast cancer and other cancers will cause lymphatic metastasis and enlargement of the lymph nodes. Anti-tumor treatment should be given according to the primary tumor in time. It should be noted that when the above symptoms appear, one should go to the hospital in time to get a clear diagnosis and then under the guidance of the doctor for treatment.