Parkinson’s syndrome is a common diagnostic concept used by neurologists in clinical practice. It refers to a group of clinical syndromes caused by various causes (cerebrovascular disease, cerebral atherosclerosis, infection, poisoning, trauma, drugs, and genetic degeneration, etc.), mainly manifesting as tremor, muscle rigidity, motor retardation, and postural instability. This includes primary Parkinson’s disease, Parkinson’s superimposed syndrome, secondary Parkinson’s syndrome and genetic degenerative disease Parkinson’s syndrome. Parkinson’s disease is characterized by resting tremor, muscle rigidity, gait and postural disturbances, and bradykinesia. Motor bradykinesia includes slow onset, freezing, small gait, panic gait, reduced spontaneous movements, writing too small, difficulty in sitting up, dysphonia, dysarthria and dysphagia. General postural instability is a symptom of late onset. In the middle and late stages of the disease, non-motor symptoms of Parkinson’s disease such as depression, constipation, sleep disturbance, and cognitive impairment may seriously affect the patient’s quality of life. 2, Parkinson’s superimposed syndrome clinical manifestations in addition to the clinical features of Parkinson’s disease, there are also prominent cone bundle signs, cerebellar atrophy, cognitive impairment, etc., the involvement of a wide range of sites, heavy symptoms, poor response to anti-Parkinsonian drugs, mainly including the following: (1) multi-system atrophy (MSA) is currently divided into two types, respectively, MSA-P and MSA-C type, where MSA P type shows symptoms of Parkinson’s syndrome such as motor retardation, and MSA-c has prominent cerebellar damage, but regardless of the type, the first symptoms of MSA are mostly autonomic symptoms, such as constipation, postural hypotension, urinary retention (or increased bladder residual urine), and erectile dysfunction in men, which can exist several years before the appearance of Parkinson’s syndrome. (2) Progressive supranuclear palsy (PSP) is characterized by pseudobulbar palsy, vertical supranuclear ophthalmoplegia, extrapyramidal muscle rigidity, gait disturbance and mild dementia as the main clinical features. Gait instability and falls occur earlier than in patients with primary Parkinson’s disease. (3) Corticobasal ganglion degeneration (CBD) is characterized by reduced movement, myoclonus, postural disorders, increased muscle tone in the limbs (upper limbs are mostly asymmetric), loss of cortical complex sensation, loss of use, and dissident limb sensory phenomenon. Dementia, gait instability and balance disorders may occur in the late stage. (4) The main symptoms of Lewy body dementia (LBD) are fluctuating cognitive impairment, Parkinson’s disease-like manifestations and hallucinations. Progressive cortical dementia is the characteristic symptom, which may be accompanied by aphasia, dyscognition, dysfunction and spatial disorientation. Some of them have Parkinson’s disease like symptoms such as muscle rigidity, reduced movement, postural disorders, gait abnormalities and tremor as their first symptoms. Secondary Parkinson’s syndrome is a Parkinson’s disease-like manifestation caused by various known causes, including vascular disease, drugs, infection, poisoning, trauma, etc. (1) Drug-derived Parkinson’s syndrome is the most common cause of secondary Parkinson’s syndrome, mostly caused by the use of dopamine-depleting agents or antipsychotics with dopamine receptor antagonism or calcium antagonists. It is most common in the elderly, mostly in women, and occurs within 3 months of drug use. Most patients have reversible symptoms that disappear after several weeks or months of discontinuation of the medication. The symptoms may include resting tremor, muscle rigidity, bradykinesia, reduced movement, postural instability, and other extrapyramidal symptoms after taking the drug. It is characterized by a rapid onset and progression. Tremor is mild or absent, but autonomic symptoms such as sweating are more pronounced, and inability to sit still and involuntary movements of the mouth, face, neck and limbs may also occur. (2) Vascular Parkinson’s syndrome mainly manifests as broken gait, gait instability, symmetrical lead tube-like muscle rigidity, lack of resting tremor, more than half of the patients have pseudobulbar palsy and cone bundle sign; the lower limbs are mainly involved, and it is not effective for levodopa treatment. 4, genetic degenerative disease Parkinson’s syndrome can be seen in children or adolescents, mainly manifested as tremor, dystonia, ataxia, cone fasciculations and mental retardation, movement disorders with some Parkinson’s disease characteristics. Common: (1) Hepatomegaly mostly has hepatic impairment and cirrhosis, and the diagnosis is confirmed by the finding of corneal K-F ring and low serum copper and copper cyanobactin. (2) Fahr’s disease is characterized by extrapyramidal symptoms, epilepsy, and mental retardation. It is important to exclude basal ganglia calcification caused by secondary factors such as hypoparathyroidism. (3) Hallervorden-Spatz disease is caused by mutations in the pantothenic acid kinase gene. Patients have multiple cone system, extrapyramidal system and cerebral cortex involvement, and MRI shows the characteristic “tiger eye sign”.