Many people or people with Parkinson’s disease or family members are often confused about the difference between Parkinson’s syndrome and Parkinson’s disease, thinking that they are both the same disease. In fact, what is commonly referred to as Parkinson’s syndrome and primary Parkinson’s disease are not the same thing. Parkinson’s syndrome is often secondary to some other diseases of the nervous system, patients can be caused by cerebrovascular disease, traumatic brain injury, intracranial inflammation, brain tumors, cerebral arteriosclerosis, hypoparathyroidism, carbon monoxide, manganese, mercury, cyanide, reserpine, phenothiazine drug poisoning and antidepressants (methylamine oxidase inhibitors, etc.) can cause Parkinson’s syndrome similar to the performance of Parkinson’s disease, so also Parkinson’s Syndrome is called “secondary Parkinson’s disease”. In addition, there are also symptomatic Parkinson’s syndrome, which is essentially other diseases of the nervous system with some symptoms of Parkinson’s disease, also known as “Parkinson’s superimposed syndrome”. The clinical manifestations of Parkinson’s syndrome and Parkinson’s disease Parkinson’s disease ≠ Parkinson’s syndrome. In terms of onset, Parkinson’s syndrome can occur in any age group, unlike Parkinson’s disease, which usually starts in middle and old age. Clinically, Parkinson’s syndrome has the same manifestations as Parkinson’s disease, such as bradykinesia, dull expression, increased muscle tone, tremor, etc. In addition, there are often manifestations left over from the primary disease, such as seizures, hemiparesis, headache, ataxia, oculomotor disorders, slurred speech, postural hypotension, dementia, etc. The imaging manifestations of Parkinson’s disease are not characteristic. Parkinson’s syndrome, on the other hand, often has corresponding changes or characteristic changes. Parkinson’s syndrome is divided into the following four categories: 1, Parkinson’s disease 2, secondary Parkinson’s syndrome: refers to trauma, poisoning, drugs, cerebrovascular disease, tumors, encephalitis and other causes of Parkinson’s syndrome 3, genetic degenerative Parkinson’s syndrome 4, Parkinson’s superimposed syndrome Parkinson’s syndrome and Parkinson’s disease are very different from the etiology and pathogenesis of the two. The cause of Parkinson’s disease is still unclear, and the pathological changes are mainly degeneration of dopamine neurons in the substantia nigra of the midbrain, so that they cannot produce enough dopamine to develop. In contrast, Parkinson’s syndrome is a syndrome of known etiology, in which the pathological changes in the brain are caused by lesions in the brain, the substantia nigra and striatal pathways, and degeneration of dopamine neurons, resulting in insufficient dopamine production or inability to transmit dopamine to maintain normal neurological function. Parkinson’s disease starts slowly and develops gradually, which means that it does not develop to a very serious degree all at once, but is a slow, progressive developmental process.