Q: Does the pacemaker work properly when I turn it on after it is installed? Drs.: The pacemaker does not work properly when it is turned on, but requires a break-in period. The pacemaker uses electrical stimulation to maintain good neurological function, so it is necessary to gradually increase the intensity of stimulation after turning on the pacemaker so that the brain can adapt to the electrical stimulation and respond well. At the same time, the dosage of medication should be adjusted accordingly to gradually bring into play the efficacy of the pacemaker and reduce the dosage of medication. This process usually takes 1 to 3 months, and some patients do not reach a relatively stable state until 6 months. Q: What conditions arise that require postoperative modulation? Drs: First of all, the most fundamental efficacy must be there. If the patient’s symptoms are not clearly improved, then definitely modulation is needed. If the symptoms improve okay, but the effect with medication is not too good, for example, after taking medication, there are a lot of motor symptoms, it is better than when not taking medication, it is necessary to adjust the medication. Again, you can go to the neuromodulation center for adjustment. Q: How often is the adjustment usually done? Doctor: Within one year after surgery, usually once every three to six months; after one year, usually once every one or two years. Q: What are the typical cases you have encountered in the process of regulation for patients? The first few steps are the preparation of the ingredients, but the cooking process is the most critical step, and the final result of the surgery is determined by the good or bad regulation. However, modulation is highly variable, and a specialized neuromodulation discipline is expected to be established in the future. I once met a patient who had a pacemaker for ten years and had relatively stable disease control for ten years, but recently had some problems. The patient’s family said that the pacemaker was still good at controlling the symptoms, but the patient felt very fatigued and felt weak in walking and talking. It was later learned that the patient was too old to sleep at night, fearing that he might not be able to turn over and cause asphyxiation when he turned over. The patient felt very anxious about this, and when she couldn’t sleep well, she felt unrefreshed and weak. Based on this situation, we asked the specialist to prescribe anti-anxiety and sleep-promoting drugs, and the patient was able to sleep well without worrying about turning over, and the effect of the pacemaker continued well. In addition, in some patients, although the effectiveness of the pacemaker is relatively stable after surgery, the effect is not satisfactory after taking the medication, so it is necessary to adjust the medication in time.