There are various causes of pain in the female vaginal opening, such as vaginitis, vestibulitis, external injury, etc. Specifically, it is recommended to go to the hospital in time for a clear diagnosis and treatment of the cause. 1. Vaginitis: Trichomonas vaginitis, pseudo-saccharomyces vaginitis, etc. can appear vulvar burning, pain, painful intercourse and other manifestations. Trichomonas vaginitis is mainly treated with metronidazole, tinidazole and other drugs, and sexual partners need to be treated together. Pseudomonas vaginitis is often treated with azole antifungal drugs such as clotrimazole, miconazole and fluconazole. 2. Vestibular adenitis: Vestibular adenitis is a rapid onset of localized swelling, pain, burning sensation, accompanied by frequent urination, painful urination and other symptoms, the treatment can choose metronidazole, cephalexin, levofloxacin and other drugs, the formation of an abscess, you can choose to choose the surgical treatment and at the same time with the drug treatment. 3. External damage: recent external impact or excessive sexual life and other factors can damage the local mucosa of the vaginal opening, resulting in pain. The symptoms can be relieved by resting and forbidding sexual intercourse, but if there is no improvement, you should consult a doctor in time.