People generally know more about breast cancer, lung cancer, stomach cancer and other tumors, but they know little about lymphoma. Professor Zhang Qingyuan said that malignant lymphoma is a type of malignant tumor that originates from lymph nodes or other lymphatic tissues and organs, and is classified into non-Hodgkin’s lymphoma (NHL) and Hodgkin’s lymphoma (HL) according to clinical and pathological characteristics. As lymphatic tissues are all over the body, lymphoma can occur in almost all parts of the body, just like the lymph nodes in the abdominal aorta and retroperitoneum of Wang, but it can also occur in the tonsils, liver, spleen and bone marrow. According to statistics, lymphoma in China is growing at an average rate of 4% per year, becoming one of the most rapidly growing malignant tumors, with about 25,000 new cases and about 20,000 deaths from lymphoma each year. Why is the occurrence of malignant lymphoma on the rise? It may be related to the following reasons: the increase of autoimmune diseases, which affect and promote the malignant transformation of lymphocytes and tissues of the main immune system of the human body; the increased level of awareness and diagnosis of malignant lymphoma; the increased incidence in middle-aged and elderly people after the increase of average life expectancy; the increased use of various immunosuppressive drugs due to the increase of patients receiving various organ transplants, which leads to the increased use of various immunosuppressive drugs, thus triggering the disorder of the immune system function; certain Specific infections, such as EBV, HIV, H. pylori, and environmental pollution, etc. The disease is most common in young and middle-aged people, with a male to female ratio of 3:1, and a family history in about 5-6% of cases. The survival of lymphoma after treatment is related to the type of disease and clinical stage. The 5-year survival rate after radiotherapy for HL is 80.5%, and the 10-year survival rate is 66.5%; the median survival of low-grade malignant NHL is 5.1-7.2 years, moderate malignant is 1.5-3.4 years, and highly malignant is 0.7-2.0 years. Within the same type, the earlier the stage of disease, the better the prognosis; within the same type and stage of disease, the prognosis is worse in children and the elderly. Most patients with lymphoma tend to present in early stages as painless lymph node enlargement, such as superficial cervical, axillary and inguinal lymph nodes, etc., as well as deep mediastinal lymph nodes in the body and abdominal lymph nodes of Tong’s onset, etc. The lymph nodes can be from soybean to egg size, tough, uniform and full, and can be accompanied by hepatomegaly and splenomegaly, and in advanced stages, failure and cachexia can occur. In addition to these local manifestations, some patients also have systemic symptoms, such as unexplained fever (excluding infection) greater than 38 degrees for more than three consecutive days, night sweats, weight loss, and itchy skin. If these abnormalities occur in the body, do not take matters into your own hands, but go to a regular hospital in time to avoid delaying the disease. Although malignant lymphoma is also a kind of malignant tumor, some patients can be cured with proper treatment. Therefore, if you are unfortunately suffering from malignant lymphoma, there is no need to be overly afraid. How can we get a cure? First of all, correct pathological diagnosis is the key. Once a lump is found and lymphoma is suspected, a pathological biopsy should be performed as soon as possible, such as surgical removal of the enlarged superficial lymph nodes or obtaining deep lymph nodes or tissue from the enlarged area in the body by puncture. These tests are safe and will not cause tumor spread or metastasis. At present, according to WHO pathological staging, lymphoma can be divided into more than 80 subtypes in detail, and the choice of treatment plan, efficacy and prognosis of each subtype are different, so it is very important that the pathological diagnosis of lymphoma must be determined by specific subtypes in a specialized oncology hospital. After getting the correct pathological diagnosis, we also need to do a comprehensive examination for the patient (usually including hematological examination, CT of head, chest and abdomen, bone marrow test, etc., and PET-CT examination can be considered if the economic condition allows), so that we can make an accurate clinical staging for the patient and then guide the future treatment. Some patients may ask: Why do I need other tests when I have a clear diagnosis of this disease? Detailed staging tests are very important. Through these examinations, we can not only know how far the tumor has developed, but also understand the status of our body, such as how the heart, lung, liver, kidney and blood functions, etc., which will help us to choose the appropriate treatment in the future. After all these tests are completed, we need to choose a treatment plan. A correct first-line treatment plan, that is, the first treatment plan, is crucial. If the patient can have a standardized and reasonable individualized treatment under the guidance of a professional physician at the beginning, it is possible to get better results and minimize the chance of tumor recurrence. There are various options for tumor treatment, such as surgery, chemotherapy and radiotherapy. For lymphoma, because it is a systemic disease, the treatment should also focus on systemic chemotherapy first, and surgery or other treatments should not be preferred. The main purpose of surgery is to obtain pathology and make a clear diagnosis, and there are also certain emergencies that need surgical solutions, such as Wang’s acute abdomen, and so on. However, it is never to rely solely on surgical resection to achieve the purpose of cure. With the advancement of science, great progress has been made in the treatment of lymphoma. One of the most important advances is the development of targeted therapy, which is commonly known as “biological missile” therapy. The most widely used is Merova, which can specifically kill tumor cells without damaging normal cells, and in combination with traditional chemotherapy can improve the treatment effect and make more people get cured. Wang also received the most benefit from this advanced “potent drug” in combination with standard first-line chemotherapy. There are various factors that determine the effectiveness of lymphoma treatment, but whether early detection, early diagnosis and persistent treatment are the key factors that determine the effectiveness of treatment. With the development of medical science and technology and intensive research, the treatment of lymphoma has made great progress, and lymphoma has become one of the tumors that can be cured by chemotherapy. Even if it is not cured, many lymphoma patients can survive for a long time through effective treatment. Therefore, lymphoma patients must have the confidence and determination to overcome the disease and actively cooperate with the doctor’s treatment.