Bone pain can be caused by a variety of reasons, and treatment will vary depending on the specific causative factor. First, the patient should be observed for trauma, falls, skin breaks, bleeding, etc. If such conditions are highly suspected, the patient should be given pain medication and pressure bandages to stop bleeding. Based on the X-ray findings, the diagnosis of fracture should be clarified and treatment should be performed by either manual repositioning or surgical incision and repositioning. If there is no such condition, the patient has no obvious trigger for the pain in the knee, hip and other large joints, which may be due to cartilage wear and collapse of the femoral head. The patient should be given non-steroidal anti-inflammatory drugs, such as Cilazol and Lapsone, immediately to eliminate inflammation and relieve pain. At the same time, the patient should be given oral medications such as Mizarin to eliminate joint edema. If the pain does not improve, it is recommended to review the MRI and give the patient minimally invasive arthroscopic surgery or artificial joint prosthesis replacement surgery according to the examination and imaging diagnosis. Acute or chronic septic osteomyelitis, which can also cause bone pain, should be treated with adequate antibiotics, thorough surgical debridement to clear the broken dead bone and drain the pus.