Duloxetine cannot be taken in half tablets. Clinically Duloxetine is a selective 5-hydroxytryptamine, with norepinephrine reuptake inhibitor. It is mainly used in the treatment of depression, generalized anxiety disorder, and chronic musculoskeletal pain. It is taken by swallowing, not chewing or crushing, so it is not possible to split Duloxetine in half and take only half a tablet. Usually after taking Duloxetine, uncomfortable symptoms such as fatigue, falls, abnormal mood, thirst, chills, weight loss, and increased blood pressure may occur. Usually it is forbidden to use it for patients with allergy to drug components and untreated narrow-angle glaucoma. Secondly, in the process of taking the drug, attention should be paid to avoid suicidal thoughts and suicidal behavior of the drug users, as well as the drug damage to the liver, it is recommended to review liver function regularly during the drug. If you need to take Duloxetine due to your condition, it is recommended that you consult a doctor after a comprehensive assessment of your condition to determine the dosage of the medication and learn the precautions to avoid taking the medication on your own to avoid adverse consequences.