The cause of obesity? ”The adult world is anything but easy to get fat!” . In real life, many people complain that it is not clear that they have gained weight. Some factors in daily life is also often the cause of obesity, how much do you know? A, obesity gene is haunted in recent years, scientists on the “obesity gene” research is happy. We also found that many obese patients in the clinic have a family history, scientists are increasingly sure that many obesity is caused by genetic genes. In July 2013, a report published in the American Journal of Clinical Investigation said that the “obesity gene” called fto can increase the level of “hunger hormone” in the body and make people more interested in high-calorie food, and thus easy to gain weight. Ghrelin, a 28-amino acid gastrointestinal peptide hormone, was first discovered to be secreted by gastric mucosal P/D1 cells and pancreatic epsilon cells. Further studies revealed that it can also be produced and secreted in the small intestine, colon, lungs, gonads, adrenal cortex, placenta, kidneys and brain. One important reason why gastric reduction surgery can be successful in weight loss is that it alters gastrointestinal hormone levels, allowing obese patients to feel less hungry and reduce their appetite. More than 200 genes or chromosomal regions associated with obesity have been identified to date. More frightening is that many of these obesity genes are in the fetal period to start the role, and the external environment will also accelerate this role. Second, improper diet improper diet is an important reason for obesity. This is mainly reflected in two aspects, on the one hand is too much food. This is easy to understand, eat more, calories can not be consumed, the accumulation of fat. On the other hand is the uneven intake of nutrition in the daily diet. First, the intake of fat and sugar content of food is too much, such as frequent consumption of fatty meat, fried food, processed meat, many sweetened foods (such as baked goods, cookies), sweetened juice, soft drinks, alcoholic beverages and refined rice and noodles and other high-carbohydrate food; second protein, vitamins, fiber and other nutrient intake is not enough. Such a diet structure is easy to lead to excessive calorie intake, the second is easy to lead to insulin resistance, the third may also lead to intestinal microbial imbalance, these are the mechanisms that trigger obesity. Third, lack of exercise physical activity is too little, calorie consumption is less, naturally easy to obesity, especially after middle age, physical labor gradually decline, fat often accumulate in the abdomen and hips. In addition, exercise less people’s basal metabolic rate will be low, the basal metabolic rate is low will make the body’s ability to consume calories is insufficient, easy to gain weight. Fourth, sleep deprivation Researchers in 1977-2012 on more than 28,000 children and 15,000 adults in the United Kingdom data analysis. The results show that sleep deprivation significantly increased the risk of obesity in adults and children. The researchers said that sleep deprivation leads to obesity may be because sleep causes hormonal changes in the body. Lack of sleep can make the gastric growth hormone (Ghrelin) secretion increase, this hormone can stimulate appetite; at the same time will lead to leptin secretion decrease, and leptin is a kind of appetite suppression hormone. Fifth, mental stress Mental factors can lead to stress eating, it generally includes two cases: the first case is when mental stress, the feeding center will be particularly excited, it is difficult to achieve a sense of satiety, people will keep eating; the second case is the role of the cerebral cortex, patients eat not to get calories, but in the process of eating to get a mood pleasure, so they will keep eating. In addition, when people are stressed, they will be prone to sleep deprivation, and in the long run, human hormone secretion will be disrupted, and sugar and fat will not be easily metabolized and consumed. Six, long-term use of certain drugs Some drugs can also lead to weight gain. According to a systematic review and meta-analysis published in 2015 in the Journal of Clinical Endocrinology and Metabolism, some drugs can cause people to gain weight within a few months. These medications include atypical antipsychotics (especially olanzapine, quetiapine and risperidone), anticonvulsants and mood stabilizers (especially gabapentin), glucose-lowering medications (such as tosylbutazone), glucocorticoids for rheumatoid arthritis and some antidepressants. It can be seen that obesity is closely related to our living habits, and controlling obesity starts with changing our lifestyle. Of course, there may be more potential factors that can trigger obesity, we will continue to explore, gradually unveil its mystery, and open up new roads for the treatment of obesity and its related diseases.