Migraine is a primary headache with episodic, cyclic and/or familial characteristics of one-sided throbbing headache, which is caused by vascular nerve dysfunction. There are two international classifications of migraine, the IHS ICHD-I in 1988 and the IHS ICHD-II in 2004, the latter being more detailed, accurate and operational than the former in terms of classification and diagnostic criteria. Migraine has become a heavy burden in China, and the annual economic loss due to migraine in China is as high as 331.7 billion yuan/year. Nine out of every 100 people suffer from migraine, and the prevalence rate of women is more than twice that of men. The degree of impact of migraine on people’s daily life also varies, with 48% of the mild cases and 24% of the severe cases. Migraine is associated with the development of cerebrovascular disease (CVD). The incidence of stroke is significantly higher in people with a history of migraine than in controls, and in young patients with thromboembolic stroke, 5% to 25% of the incidence is associated with the development of migraine. 14 studies analyzed by MeTa concluded that the risk of stroke in migraine was increased twofold. A controlled study showed that stroke was only associated with migraine. Migraine can also be induced by cerebral ischemia. The following types of migraine are more closely associated with cerebrovascular disease. In determining the association between migraine and CVD, the following principles should be followed: (1) symptoms of neurological deficits resemble the aura symptoms of previous attacks; (2) stroke occurs during a typical migraine attack; and (3) other causes of stroke are excluded. I. Retinal migraine Retinal migraine? This type of migraine is usually seen in young people, with recurrent attacks of blurred vision or loss of vision in one or both eyes, each attack lasts for a few minutes or less than 1 h. There is often a headache before or between attacks. The interictal period is completely normal. Funduscopic examination shows optic disc edema and occasionally cherry red macular changes. II. Basilar artery migraine Basilar artery migraine? This type is more common in young women, and the attacks are mostly related to menstruation. The prodromal symptoms are mostly flashes, dark spots, blurred vision, hallucinations, shyness or total blindness. This is followed by brainstem symptoms, including vertigo or dizziness, ataxia, dysarthria, tinnitus, perioral or tongue numbness, and limb weakness. After lasting 2 to 60 min, these symptoms disappear and a headache attack occurs. Cone bundle signs, inter-nuclear ophthalmoplegia, and facial palsy may occur during the attack. In a few cases, impairment of consciousness, sudden collapse attack, atresia syndrome, convulsions, medullary or cerebellar infarction, and unremarkable vertebral artery or posterior cerebral artery may occur. III. Oculomotor paralysis migraine Oculomotor paralysis migraine? Although it can occur in infants and children, the age of onset of this type is basically the same as that of common type migraine. Oculomotor palsy is usually caused by the involvement of the arterial ophthalmic nerve and the spreading nerve, and may coexist with the headache or appear within a few days to 2 months after the headache subsides and disappear after a few days to a few weeks. Multiple recurrent episodes may result in persistent ocular muscle palsy. In addition to oculomotor and adductor nerve involvement, the ophthalmic branch of the trigeminal nerve may also be involved, and low density foci in the ipsilateral temporal lobe and parieto-occipital region may be seen on CT. It is rare to have only ocular muscle palsy without headache. IV. Hemiplegic migraineHemiplegic migraine? There are two types of migraine: familial and epidemic, and the former is mostly chromosomal dominant. Hemiplegia can occur as an aura symptom of headache or after the headache disappears, but the former is more common. Most CSF or MRI examinations are normal, but a few cases show signs of cerebral hemispheric edema. The mechanisms involved in the complication of migraine with cerebrovascular disease are not fully understood and may be related to the tendency of migraine cases to be associated with abnormal vascular development, vasospasm, microembolism, thrombosis and interstitial aneurysm. Risk factors for migraine and stroke include: smoking, hypertension, hypercholesterolemia, female and taking birth control pills. In imaging, the frequency of migraine attacks correlates with the rate of white matter changes in the brain on MRI. Several studies have suggested that migraine and cerebrovascular disease may share common mechanisms, such as similar risk factors and genetic factors. In addition, migraine can promote the release of active substances that damage blood vessels, and the resulting ischemia may be one of the mechanisms by which migraine causes stroke. To determine the association of migraine with cerebrovascular disease, the following principles must be followed: (1) the diagnosis of migraine must conform to the criteria established by the International Headache Society (1988); (2) the onset and resolution of symptoms of neurological deficit are closely related to the time of migraine onset, and it is characterized by short duration and repeatability; (3) other causes of cerebrovascular disease, such as intracranial aneurysm or vascular malformation, arteritis and pharmacogenic headache, are excluded. headache, etc. Symptomatic treatment and prevention Treatment principles and methods are the same as those for general migraine patients, and those with evidence of cerebral infarction, microembolism or vasospasm can be treated with calcium antagonists and anti-platelet coagulation drugs.