Blisters after spotting with medicated water are mostly considered to be contact dermatitis, which can be treated by general treatment, topical medication and systemic medication. 1. General treatment: first of all, avoid re-exposure to this kind of medicine, use water or saline to rinse the blisters and the surrounding skin, avoid scratching and squeezing, keep the wound clean. 2. Topical medication: use glucocorticosteroids (such as hydrocortisone cream, compound dexamethasone ointment, etc.), antibiotics (such as fusidic acid, etc.) and other drugs to carry out anti-inflammatory and anti-allergy treatment. 3. Systemic medication: antihistamines such as loratadine and ebastine can be taken, together with glucocorticoid drugs such as prednisone tablets and dexamethasone tablets. After blistering after spotting, it is recommended to go to regular medical institutions in time and follow the doctor’s instructions to avoid blind self-medication, so as not to cause adverse consequences.