Unconjugated bilirubin is bilirubin that is not bound to glucuronic acid. Causes of high unconjugated bilirubin. I. Liver disorders, such as acute jaundiced hepatitis, acute liver necrosis, chronic active hepatitis, liver cirrhosis, etc. Second, hemolytic anemia, a large number of red blood cells in the body destroy and release unconjugated bilirubin. When there is too much unconjugated bilirubin in the blood, it exceeds the conversion capacity of the liver, so that the unconjugated bilirubin stays in the blood, thus the unconjugated bilirubin in the blood is high, this condition is also called hemolytic jaundice. Patients usually have yellow skin and yellow urine. Third, blood type incompatibility transfusion. When blood of incompatible blood types is given, hemolysis results, causing massive destruction of red blood cells in the body, which leads to high unconjugated bilirubin in the blood. Four, hepatocellular jaundice, when the liver cells are diseased or because bilirubin can not be converted into bile properly or because of swelling of the liver cells so that the bile ducts in the liver are under pressure to drain, bile is blocked, so that the bilirubin in the blood is elevated. V. Neonatal jaundice. When jaundice appears in newborns 48-72 hours after birth, with bad spirits and does not subside within 2 weeks, it is mainly caused by maternal and child blood type or congenital biliary malformation in newborns. This condition also leads to high levels of unconjugated bilirubin in the blood.