The human brain is the center of higher neural activity, and the cerebral cortex is the most important material basis for mental activity. The front half of the cerebral hemisphere is the area responsible for learning, memory, emotion, thinking and other higher neural activities. The human brain has about 14 billion nerve cells, which die about 100,000 per day in adulthood, and brain cells can be reduced by 10% to 20% in aging, and in some cases even by 30%. The main cause of brain cell changes in the elderly is the increase in brain cell death, resulting in brain cortex atrophy and weight loss. Patients with Alzheimer’s disease have 40% to 50% less brain weight than normal people of the same age, and the reduction of brain cells can also reach 40% to 50%. Brain atrophy is diffuse, with the frontal lobe being the most obvious. It can be seen that cortical atrophy is the main pathological basis of Alzheimer’s disease, but the real pathogenesis is not yet well understood.