Chronic hepatitis B patients with abnormal liver function (aminotransferase increase) is not a bad thing, on the contrary, it is a hint that the body’s immune function in the clearance of the virus, but some patients found that the aminotransferase is high, they are nervous, hoping to take “liver-protecting drugs” immediately bring down the aminotransferase, in fact, it is a misunderstanding, the light of the “liver-protecting”, can not cure chronic hepatitis B, should be antiviral treatment. In fact, it is a misunderstanding, light “liver protection”, can not cure chronic hepatitis B, should be antiviral treatment, so what transaminase level for antiviral treatment effect? Generally speaking, the best level of alanine aminotransferase (ALT) in liver function should be around 200U/L, with a maximum of not more than 500U/L, and without jaundice, because too high a level of aminotransferase, although suggesting a strong ability to clear the hepatitis B virus, also suggests that the liver cells are severely damaged, which may be life threatening. (Note that the transaminase abnormality I am referring to here is caused by the body’s immune function against the hepatitis B virus destroying liver cells, and is not caused by alcohol, drugs, steatohepatitis, autoimmune liver disease, or other bacterial or viral infections). Of course, it should not be wrongly understood that the longer the liver function abnormality, the better, because there is inflammation, necrosis, there is repair, and this repair process will have fibrin formation and deposition, which will lead to liver fibrosis over time, and gradually form cirrhosis.