Total bilirubin 22.2 is mildly elevated, which may be related to pathological causes such as fatty liver, chronic hepatitis, or physiological causes such as prolonged late-night sleep and lack of rest, or improper diet. 1. Physiological reasons: long-term irregular work and rest, often stay up late, less rest time, or irregular diet, excessive spicy and greasy food and other factors may make the total bilirubin mildly elevated. 2. Pathological causes: Fatty liver, chronic hepatitis such as hepatitis B, hepatitis A and other diseases may cause a mild increase in total bilirubin. It is recommended to consult a doctor and improve the relevant examination. The total bilirubin 22.2 test result alone can not accurately determine the cause, but also need to be combined with the characteristics of the medical history, other test results to make an accurate judgment, it is recommended to clarify the cause of the disease under the guidance of a doctor.