Fluconazole and metronidazole can be used together, but you need to follow the doctor’s instructions for medication. Fluconazole is commonly used in the form of capsules and injections, and is an antifungal drug. It is used for the treatment of cryptococcal meningitis, coccidioidomycosis, invasive candidiasis, mucocutaneous candidiasis, etc. It is also used for the prevention of recurrence of cryptococcal meningitis and recurrence of oropharyngeal or esophageal candidiasis. Fluconazole adverse reactions include headache, nausea, vomiting, abdominal pain, diarrhea, elevated aminotransferases, elevated blood alkaline phosphatase, and skin rash. The drug is contraindicated in people who are allergic to fluconazole. The use of fluconazole prohibits the use of terfenadine, astemizole, cisapride, erythromycin, pimozide, quinidine and other drugs. Metronidazole commonly used dosage forms are tablets, injections and so on. It has the effect of killing trichomonas and inactivating anaerobic bacteria. It is used for the treatment of amoebiasis, but also for the treatment of vaginal trichomoniasis, cutaneous leishmaniasis, pouch worm disease, guinea worm infections, and the treatment of anaerobic bacterial infections. Adverse reactions to metronidazole include abdominal cramps, loss of appetite, nausea, vomiting, headache, and vertigo. The drug is contraindicated in patients with blood disorders and active central nervous system disorders. Fluconazole and metronidazole instructions do not point out that the two will occur drug interactions, there is no contraindication, can be taken together, but both have adverse reactions to the gastrointestinal tract, should be followed by a doctor’s advice for rational use.