A high total liver protein is not necessarily a problem. High total protein can occur in normal people, such as those who are well-nourished. In addition, certain physiological factors can also cause high total protein, such as strenuous exercise or intense physical work. High total protein may also be caused by diseases, such as viral hepatitis, autoimmune liver disease, multiple myeloma, macroglobulinemia, rheumatoid arthritis, and systemic lupus erythematosus. The concentration of total protein can also be increased by blood concentration, such as severe vomiting, diarrhea, sweating, severe dehydration due to hyperthermia, and shock. Total protein reflects the synthesis and metabolic capacity of the liver, as well as the reserve capacity of the liver, so the value of total protein can be used to assess the function of the liver.