A course of chemotherapy for liver cancer usually lasts for about 2 days, which is related to the chemotherapy regimen and patient’s tolerance. Liver cancer is one of the common malignant tumors in digestive system. There are no obvious symptoms in the early stage, and with the aggravation of the disease, abdominal pain, jaundice, digestive symptoms, systemic abnormal manifestations, etc. can appear. Domestic guidelines point out that FOLFOX4 regimen is approved for the first-line treatment of locally advanced and metastatic hepatocellular carcinoma that is not suitable for surgical resection or local treatment in China. FOLFOX4 regimen is as follows: oxaliplatin (L-OHP) intravenous drip for 2h, d1; calcium folinic acid (LV) intravenous drip for 2h d1 and d2; 5-fluorouracil (5-FU) 400mg/m2 intravenous push for d1 and d2; 5-fluorouracil (5-FU) continuous sedation (civ) for 22h d1 and d2; and 14 days for a week. It is better for liver cancer patients to combine with the guidance of professional doctors to choose a solid chemotherapy program. If patients are not sensitive to chemotherapy or cannot bear the side effects of chemotherapy, they can choose comprehensive treatment to prolong their survival period as much as possible. Please strictly follow the doctor’s prescription for drug treatment and do not use drugs by yourself.