Hard lumps under the skin of the buttocks with painful pressure may be caused by folliculitis, sebaceous cysts, hemangiomas and so on, which can be treated under the guidance of the doctor through general treatment, medication (fusidic acid, propranolol ointment, etc.), surgery and other methods. 1. Folliculitis: the disease is mainly due to bacterial, fungal and other pathogens caused by hair follicle infection, but also with the body’s immune function, allergic reaction, etc. Patients need to keep the skin clean, protect the skin, avoid injury, accelerate the recovery of the lesions, prevent the spread of infection, but also through drug therapy, such as fusidic acid, mupirocin, cefuroxime and so on. In the advanced stage of pus and ruptured ulcers, the pus can be discharged through surgery by incision and drainage, and if the hard lumps are very large, surgical resection can be performed. 2. Sebaceous cysts: due to the sebaceous gland excretory duct obstruction, swelling and the formation of retention cysts, will lead to the patient’s buttocks subcutaneous hard lumps painful pressure, can be under the guidance of the doctor, through the conventional surgery will be excised cysts, when the complication of infection fluctuation, need to be incised and drained. 3. Hemangioma: when the balance between angiogenic factor and angiogenic inhibitory factor is out of balance, as well as the mutation of some pathogenic genes or inactivation of oncogenes, which leads to pain when pressing the hard lumps under the buttocks, patients need to pay attention to rest, avoid too much fatigue, and take proper exercise, which is conducive to the increase of vascular elasticity, and can also use propranolol ointment, prednisone and other medicines to carry on the treatment. All of the above drugs should be used in accordance with medical advice. It is recommended that patients go to the hospital in a timely manner, under the guidance of the doctor for symptomatic treatment.