From ancient times to the present, human beings have had a fear of disease and a desire for longevity. As early as the Qin Dynasty, the first emperor completed the unification of China and became invincible, only death became the only worry. In order to achieve immortality, he spent huge sums of money and sent a fleet of ships to the East China Sea to look for immortal herbs, but finally he woke up and his dreams were dispersed, and he was buried with his soldiers and horses. Aging is an inevitable law of life, irresistible, but we can work hard to maintain a good state of health. For example, “a 60-year-old person has the heart of a 30-year-old”. The actual age of 60 cannot be changed, but the biological age of 30 is controllable. In the past 10 years, Academician Chen Xiangmei has been the chief scientist of 973 research on “aging and related diseases of aging”, hoping to solve the problem of “what is aging, why aging, and how to delay aging”. Currently, international research is trying to find the formula between “biological markers of aging” and “biological age” to assess “real age” and “biological age”. “If the two are not equal, there must be an accelerated or delayed aging of an organ. Academician Chen’s team found that in addition to the immune system, bones and nerves, the immune system and bone marrow age rapidly, reaching 1.1% per year after age 40, while the kidney ages at a rate close to 1%. Foreign research shows that there are more than 10 factors that affect aging, including “individual well-being”, which includes 3 aspects: individual satisfaction with life, satisfaction with the current situation and happiness. However, the results of our survey of more than 4,000 rheumatologists in China show that the happiness of doctors is even lower than that of patients. The influence of more than 10 factors on aging is the result of a combination of effects. Delaying aging should take into account various factors such as the internal and external environment of the organism, and the happiness of the individual, i.e., the state of mind, has a great impact on the speed of aging. How to delay aging is to achieve the 3 points advocated by WHO (World Health Organization) – “physical and mental health, absence of disease, and social survival value”. Studies have found that genes can affect the rate of aging, and limiting energy metabolism and anti-oxidation can help slow down aging; the intra-individual environment is also important to the rate of aging. In 2012, the journals Nature and Science reported that replacing the blood of old rats with that of young rats can slow down aging, indicating that changes in the intra-individual environment can also affect the rate of aging. In the effort to conquer disease, our ancestors paid a heavy price. In the West, cruel treatments such as bloodletting, emetic, catheterization, and herpetology became classic treatments, adopted regardless of the disease, resulting in the deaths of countless people, including Washington, the founding president of the United States. In 2007, academician Wu Mengchao and Dr. Xiao Fei jointly proposed the concept of “living with disease”, which, according to Wu, involves a change of concept, in order to transform incurable malignant diseases into benign ones. The progress of the disease is brought to the grave. Professor Shen Feng believes that there are two important implications: first, the development of modern medical technology makes it possible for patients to “live with the disease” for a long time. Secondly, there are many “over-treatment” phenomena in clinical practice, which not only cause harm to patients, but also waste medical resources. Promoting “living with the disease” can better promote patients to live with the disease in a stable condition after treatment, and can also effectively avoid patient harm and medical waste. In 2012, the U.S. FDA and four other medical authorities jointly proposed the “Living with Disease” initiative, which coincided with the views of Chinese doctors five years ago. Rheumatologists have a better understanding of “living with disease”. Many rheumatic diseases such as rheumatoid arthritis and systemic lupus erythematosus are difficult to be “completely cured”, and the goal of treatment pursued by doctors is “clinical remission” or “controlling the disease to the lowest disease activity The goal of treatment that doctors pursue is “clinical remission” or “control of the disease to the lowest disease activity”. When the patient’s disease is in remission to a certain degree, it is a more scientific concept to follow up the patient and adjust the treatment plan in time. There are 2 misunderstandings in the clinical attitude of patients toward the disease: some patients attach great importance to the disease and hope to “completely cure” the disease that cannot be cured by current medicine through the best drugs; some patients do not care about the disease and stop treatment on their own when the joint and kidney symptoms are not completely relieved, resulting in recurrent attacks; most patients Most patients have an attitude between the two. He believes that we should promote the concept of “living with the disease” to patients, treat chronic diseases such as rheumatism correctly, advocate scientific treatment and standardized treatment, and finally achieve “living with the disease”. Academician Chen Xiangmei agrees with the concept of “living with the disease” and believes that in addition to doctors, this concept should be promoted to patients. On the one hand, this can help patients adjust their mindset, improve compliance and better cooperate with doctors. For example, except for acute nephritis and kidney damage caused by specific reasons, most of the kidney diseases are chronic diseases with a chronic progressive process. On the other hand, over-treatment is avoided to avoid the development of psychological disorders in patients. For example, a young child who develops hematuria in childhood can have a good prognosis after timely intervention, without affecting normal working life. If parents are overly anxious about it and travel all over the country to seek medical help, it can greatly affect the child’s mental health and cause a “psychological disability”. At present, the Chinese public is generally lacking in basic medical knowledge, which leads to the lack of awareness of chronic diseases and tension between doctors and patients. Minister Chen Zhu of the Ministry of Health once said in a question-and-answer session that he hoped the majority of rural friends could learn more about diseases and take better care of their organs. Academician Chen called for the concept of “living with disease” to be promoted to doctors, patients and family members as well as to help patients better understand disease, cope with disease and achieve health. Nephrologists are confident that patients with chronic kidney disease can age and die naturally like normal people. Compared to surgeons who see immediate results after surgery, perhaps this is the greatest success of internal medicine doctors. Academician Wu Mengchao said: the progress of medicine needs to be explored continuously, to study the inner meaning of the “God particle”, and to move forward step by step. The meeting talked about the history of medical development, from understanding disease, scientific assessment, to diagnosis and treatment, in the continuous improvement, so that patients are getting healthier and living longer, each of the research ideas and the progress brought by this is the God particle. The key is that we must keep exploring with scientific attitudes and ideas for patients.
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