Patients who take hormones for a long time and in high doses are prone to aseptic osteonecrosis. As a result, some rheumatic patients are reluctant to take hormones, leaving the disease uncontrolled. Hormones are indeed an important cause of aseptic osteonecrosis, but there is also evidence that chronic vasculitis is present in necrotic bone biopsies regardless of whether the patient has received hormone therapy, so it is thought that vasculitis in rheumatism itself can lead to osteonecrosis and that hormones are not the only cause of aseptic osteonecrosis. Some patients who develop aseptic osteonecrosis are not suffering from rheumatic disease. In some patients, aseptic osteonecrosis occurs after taking hormones for only one week, which indicates that the occurrence of aseptic osteonecrosis is also related to the sensitivity of the individual. Alcohol and painkillers can also cause aseptic osteonecrosis. Expert tips: The use of hormones and dose size should still be selected by experts according to the degree of disease activity, because of the side effects of hormones and delay the best time to treat the disease, eventually causing uncontrollable disease activity, and even affect life, is a more terrible consequence than aseptic osteonecrosis.