High immunoglobulin IgE can be caused by allergic reactions, parasitic infections and other diseases. 1. Allergic reaction: allergic rhinitis, allergic asthma, urticaria and other diseases are common. It is mainly due to the allergens into the body, so that the TH2 over-activation, resulting in TH2 cell hormone secretion is too high, promote the B cells to produce more immunoglobulin IgE. can be appropriate to give anti-allergy drugs, such as cetirizine, diclofenac tadalafil, and so on. 2. Parasitic infection: It is one of the common causes of high immunoglobulin IgE. After exclusion of no obvious allergens, should consider the existence of intestinal parasitic disease, can further do stool worm egg examination. If the eggs are detected, worms can be killed, such as levamisole. 3. Other diseases: some liver diseases, rheumatoid arthritis can also cause high immunoglobulin IgE. When the immunoglobulin IgE is high, you should consult the doctor in time and follow the doctor’s instructions.