Women with urinary tract infections may experience itching in the urethra, often due to mycoplasma, chlamydia, and gonococcal infections. These pathogenic infections can be accompanied by burning and itching in the urethra, or increased discharge from the urethra. However, non-specific urethritis does not cause itching or burning in the urethra, and in most cases, it only causes symptoms such as frequent urination, urgency, and pain during urination. Therefore, when urinary tract infections and itching in the urethra occur, it is recommended to undergo tests for mycoplasma and chlamydia to further clarify the presence of related pathogens. Mycoplasma Chlamydia infection is often seen after unclean sexual contact, resulting in an associated infection, so it is also a type of sexually transmitted disease. The infection needs to be treated with targeted macrolide antibiotics so that the symptoms of itching in the urethra can be gradually relieved. It is best if patients can collect specimens of urine or urethral secretions for bacterial culture or mycoplasma-chlamydia culture to identify the source of infection and provide targeted treatment.