Urine leukocytes plus or minus number, there may be urine specimen contamination, generally need to be rechecked, if the results are correct may be the presence of urinary tract infection, stones, etc., as follows: 1. urine specimen contamination: such patients often do not have the symptoms of urinary frequency, urinary urgency, urinary pain, by rechecking the urinary routine, the leukocytes return to normal, is related to the urine specimen contamination, do not need to be treated; 2. Urinary system infection: often there will be symptoms of urinary frequency, urinary urgency, urinary pain, and even discharge from the external urethra, at this time the urine leukocytes plus or minus number, generally can be diagnosed as a urinary tract infection. Usually, quinolone antibiotics can be applied for treatment; if the patient is <18 years old, or in the stage of pregnancy or breastfeeding, cephalosporin antibiotics can be considered for treatment, and cefaclor is commonly used clinically. Before use, it is necessary to pay attention to whether the patient has a history of allergy to cephalosporin antibiotics; clinically, treatment can also be carried out with drugs that clear heat and lymphatic flow in Chinese medicine, such as Urine Clear Tablets and Bazheng Capsules. If the patient's symptoms are reduced or even disappear after treatment, and the white blood cells return to normal when the urine routine is rechecked, it means that the patient has reached clinical cure; 3. Urinary stones: If the patient has urinary stones, the patient may have renal colic. If a sharp stone slips through the mucosa of the urethra, hematuria may occur on the one hand, and an increase in leukocytes on the other. If the stone is relatively small, the patient can drink a lot of water to increase the urine volume and help the stone to be expelled. In addition, pay attention to a balanced diet, moderate intake of animal protein and avoid eating animal offal. Medication, such as oral thiazides, can be taken, and extracorporeal shock wave lithotripsy can also be considered. If the stone is large, has affected the kidney function or drug treatment is ineffective, without extracorporeal shock wave lithotripsy conditions, it is recommended to consider surgery.