New drugs for hypertension with a shot of slow release for 20 years does not exist, there is currently no new clinical drugs for hypertension with a shot, the treatment of hypertension is still based on oral antihypertensive drugs. 1. Diuretics: diuretics reduce peripheral vascular resistance by increasing sodium excretion and decreasing extracellular volume, as a way to achieve the purpose of lowering blood pressure. Such as hydrochlorothiazide, furosemide and so on. 2. β-blockers: mainly through the inhibition of myocardial contractility, slowing down the heart rate to play a role in lowering blood pressure. Such as bisoprolol, metoprolol and so on. 3. Calcium channel blockers: block calcium channels, reduce extracellular calcium ions into the vascular smooth muscle cells, reduce resistance vasoconstriction reaction to lower blood pressure. Such as nifedipine, amlodipine and so on. 4. Angiotensinase inhibitors: through the inhibition of angiotensinase to inhibit the strong vasoconstrictor effect of angiotensin, so as to lower blood pressure. Such as valsartan, irbesartan, etc.. 5. Angiotensin receptor inhibitors: similar to the fourth type of action, but the drug is to inhibit the angiotensin receptor. Such as captopril, perindopril and so on. The choice of hypertension drugs need to be selected according to the patient’s specific situation, not blindly applied, need to go to the hospital, please doctor’s guidance on the use of drugs.