Newborn babies’ nose huffing and puffing is a common symptom in this age group. Whether it is normal or not needs to be assessed in conjunction with other abnormalities (e.g. fever), such as fever and spitting up in combination, which are abnormal. Newborn infants respiratory system is not well developed, the nasal cavity is narrow, the nasal mucosa is tender, and rich in blood vessels, easy to be affected by environmental factors and pathogens, nasal congestion, runny nose, manifested as “nose huffing and puffing,” which is a common symptom in this age group. If a newborn baby is in an indoor environment with a low temperature, and there is no obvious discomfort (e.g. fever, spitting up or coughing), and the mental response is good, the above symptoms may also occur, which is usually not considered abnormal, and the indoor temperature can be adjusted as appropriate, paying attention to the baby’s warmth. If a newborn baby’s nose is huffing and puffing and there are symptoms such as elevated temperature, spitting or coughing, it is usually considered abnormal and may be a respiratory infection that requires active diagnosis and treatment to avoid delay in treatment. Parents should be vigilant when their newborn baby’s nose is huffing and puffing, and are advised to seek medical consultation and assessment by a specialist if necessary.