Gastroesophageal reflux disease is the reflux of duodenal contents into the esophagus causing heartburn and other symptoms, and is divided into reflux esophagitis and non-erosive reflux disease according to whether it leads to esophageal mucosal erosion and ulceration. Common medications are as follows: 1. Gastrointestinal motility drugs such as domperidone, mosapride, etopride, etc. These drugs may reduce esophageal reflux of gastric contents and reduce their exposure time in the esophagus by increasing LES pressure, improving esophageal peristaltic function, and promoting gastric emptying. Since the efficacy of these drugs is limited and uncertain, they are only indicated for patients with mild disease or as an adjunctive treatment in combination with acid-suppressing drugs. 2. Acid-suppressing drugs are effective in reducing the effects of damaging factors and are currently the main treatment for this disease. For patients receiving treatment for the first time or those with esophagitis, treatment with proton pump inhibitors (PPI) is appropriate in order to rapidly control symptoms and cure esophagitis. (1) PPI is a strong acid-suppressing drug: it is more effective than histamine H2 receptor antagonists and is suitable for patients with severe symptoms and esophagitis. General treatment of peptic ulcer conventional dosage, the course of treatment for 4-8 weeks, for individual ineffective doubling the dose or promote gastrointestinal motility drugs used in combination, and appropriate to extend the course of treatment. (2) H2 receptor antagonists: such as ranitidine, famotidine, etc. This drug can reduce 50%-70% of 24-hour gastric acid secretion, but cannot effectively inhibit gastric acid secretion caused by feeding stimulation, so it is suitable for patients with mild and moderate symptoms. 3. Antacids are only used for patients with mild symptoms and intermittent episodes as temporary relief of symptoms. These are the drugs for the treatment of GERD. When symptoms appear, do not take the drugs blindly, and specific medication should be taken under the guidance of clinicians.