Patients with headache accompanied by vomiting should mainly be treated for headache and antiemetic treatment at the same time. Clinically used headache drugs, mainly ibuprofen, naproxen, acetaminophen, aspirin, antiemetic drugs mainly metoclopramide and prochlorperazine. At the same time, we should actively search for the causes of headache, and carry out corresponding treatment for the causes. Clinically, there can be a variety of diseases causing headache, such as intracranial organic lesions, including intracranial tumors and cerebrovascular diseases, and patients with intracranial tumors are generally treated with surgery or radiation therapy. Cerebrovascular diseases include cerebral hemorrhage, subarachnoid hemorrhage and cerebral infarction, which should be actively hospitalized for comprehensive treatment. In addition, also seen in the primary headache disease, such as migraine and cluster headache, primary headache is mainly symptomatic treatment.