If small particles appear at the glans or the coronal groove, then the possible causes and treatments: 1, penile pearl rash. Often seen in patients with prolonged prepuce or prepuce, after turning over the foreskin externally at the coronal groove or the prepuce tie, a granulation-like structure can be seen, the surface is smooth, there is no secretion, there is no pain, there is no odor and so on. Often may be related to the local chronic stimulation of proliferation, it is a normal physiological changes, can be without treatment, and the disease is not progressive and contagious, such as excessive concern can be under anesthesia for local cauterization. 2, acromegaly. It is a disease transmitted by sexual contact, caused by HPV virus infection. When the infection occurs can appear glans, coronary groove, urethral orifice, the inner plate of the foreskin, and even the perineal area, perianal and other places of the granular structure, the surface of the cauliflower-like, not smooth, there can be bloody secretions, accompanied by a certain odor and malodor, causing the patient’s skin itching, pain, the need for surgical excision. Pathologic examination is performed after surgery, and antiviral treatment is required if acromegaly is confirmed.