Pus discharge from the penis, accompanied by painful urination may be due to: first, gonococcal urethritis, which is usually referred to as gonorrhea, which is a sexually transmitted disease, the diagnosis needs to be retained pus secretions, gonococcal smear and culture tests, such as smear or culture gonococcal bacteria can be found to confirm the diagnosis. Treatment requires intravenous infusion of ceftriaxone sodium 1g twice daily for 7-10 days. Sexual intercourse is forbidden during the treatment to avoid infection of the partner, and the improvement of symptoms is observed after the treatment. Secondly, non-gonococcal urethritis is caused by mycoplasma and chlamydia infection, is also a sexually transmitted disease, the diagnosis needs to be retained secretions for mycoplasma and chlamydia culture, such as culture results are positive can be diagnosed. Treatment is recommended to use macrolide antibiotics for treatment, intravenous infusion of azithromycin 0.5g drip, once a day, continuous drip 7-10 days. Sexual intercourse is forbidden during the treatment period to avoid partner infection.