Meniere’s syndrome, or Meniere’s disease, is caused by the accumulation of water in the membranous labyrinth of the inner ear, which causes recurrent episodes of visual vertigo, tinnitus, and fluctuating hearing loss. The treatment of dehydration in this disease refers to the application of dehydrating agents, which can enhance the permeability of the vascular wall and reduce the edema of the membranous labyrinth in order to alleviate the symptoms and promote the recovery of the disease. Commonly used drugs are hydrochlorothiazide and chlorothiazide. 1. Hydrochlorothiazide: This drug can treat edematous diseases, excrete excessive sodium and water in the body, reduce extracellular fluid volume and eliminate edema. Common ones include congestive heart failure, cirrhotic ascites, nephrotic syndrome, acute and chronic nephritis edema, early chronic renal failure, sodium and water retention due to adrenocorticotropic hormone and estrogen therapy. 2. Chlorthalidone: This drug is used in edematous diseases to excrete excessive sodium and water in the body, reduce extracellular fluid volume and eliminate edema. Common ones include congestive heart failure, ascites in cirrhosis, nephrotic syndrome, edema in acute and chronic nephritis, early stage of chronic renal failure, sodium and water retention due to adrenocorticotropic hormone and estrogen therapy. Dehydration treatment for Meniere’s disease needs to follow the doctor’s instructions and standardize the use of medication under the guidance of the doctor.