Pain relief for pain in the heel joint of the big toe depends on the exact cause of the pain. If it is caused by damage to the joint and the surrounding muscles, tendons, and ligaments in this location, you can usually take oral non-steroidal anti-inflammatory painkillers, such as nimesulide, diclofenac sodium, loxoprofen sodium, and other medications are able to effectively reduce local inflammation, reduce inflammatory edema, and no longer have stimulation of peripheral nerves in the surrounding area, the symptoms will get significantly better. If it is gout, gout is due to the first metatarsophalangeal joint position of the big toe gout stone or inflammatory changes, resulting in localized obvious pain, usually need oral colchicine for gout in the acute phase of pain relief, but often combined with a lot of gastrointestinal symptoms, such as abdominal pain, diarrhea, abdominal distension, acid reflux, nausea, vomiting and so on. In addition, oral anti-inflammatory painkillers can be taken, such as the above mentioned diclofenac sodium, nimesulide and so on can also be effective in reducing inflammation. However, after the pain has been relieved, you can switch to oral probenecid tablets or allopurinol to effectively inhibit the increase of uric acid and reduce the symptoms of gout.