Esophageal neurosis can be relieved and treated with antidepressants such as paroxetine and gastric stimulants such as domperidone. Esophageal neurosis is a psychosomatic related disorder that may manifest with symptoms such as throat discomfort, foreign body sensation, and obstruction, but no abnormality is found on examination. Patients are usually accompanied by mental and emotional symptoms such as anxiety, depression, loss of appetite and insomnia. 1. Antidepressants: (1) Paroxetine: it is a new type of selective 5 hydroxytryptamine reuptake inhibitor, which can be used for the treatment of depression, obsessive-compulsive disorder, panic disorder and social fear, as well as for the treatment of generalized anxiety disorder and so on. (2) Venlafaxine: It is a selective 5 hydroxytryptamine and norepinephrine reuptake inhibitor for various types of depression, including depression with anxiety and generalized anxiety. 2. Gastrointestinal stimulants: drugs such as domperidone and prucalopride can effectively promote gastrointestinal motility and improve symptoms such as nausea, vomiting and loss of appetite. Esophageal neurosis can also use olanzapine and other antipsychotics for relief, it is recommended to consult a doctor in time to clarify the diagnosis and targeted treatment. In addition, all of the above drugs should be taken under the guidance of a doctor, not unauthorized use of drugs.