The difference between one-time eradication of perianal abscess and drainage mainly includes the use of scenarios, surgical difficulty, and postoperative complications. 1. Scenario: Drainage of perianal abscess is aimed at larger abscesses where the internal opening cannot be found and the border is not clear, to relieve the symptoms; while one-time radical surgery is aimed at removing the fistula while incising and draining pus from the abscess. 2. Surgical difficulty: perianal abscess drainage is generally less difficult to operate, while the one-time radical surgery is more difficult to operate, the two need to be based on the specific condition of the judgment for decision-making. 3. Post-operative complications: drainage due to the lack of treatment of the inner mouth, it is easy to fistula; while radical surgery to excise the inner mouth, basically can be cured, without the need for multiple surgeries. Therefore, there is a certain difference between radical surgery for perianal abscess and drainage surgery, and you need to choose the treatment according to the doctor’s professional opinion in the clinic.