Refractory pain, such as cancer pain patients, patients with sequelae of shingles, or some unexplained pain, the treatment of these patients, the choice is very narrow, such as we often take drugs or nerve block, etc., the effect of the treatment of these patients are not too obvious, so we call it refractory pain. Of course, intractable pain it has a cause, we must find out its underlying causes, targeted treatment, to take a comprehensive approach to treatment, so that patients can reduce pain.