Refractory tuberculosis, as the name suggests, relative to ordinary tuberculosis, manifested as a tuberculosis with greater difficulty in treatment and poorer therapeutic effect. Mainly manifested in the following aspects: 1, for the difficulty of medication, such as drug-resistant tuberculosis patients, can not use the drug, the mortality rate will be greatly increased, and the treatment effect is not good; 2, some patients, tuberculosis drug treatment, but the physique is different from others, once the use of medication, there will be a lot of adverse reactions, such as can be serious gastrointestinal tract reactions, liver function impairment, allergic reactions, resulting in tuberculosis drugs can not be used, treatment Difficulty will be increased, which also affects the treatment effect to a certain extent; 3, some tuberculosis is multi-organ tuberculosis, with a wide range of foci, combined with tuberculous meningitis, bronchial tuberculosis, intestinal tuberculosis, liver tuberculosis and other multi-organ tuberculosis, which increases the difficulty of the treatment to a certain extent; 4, tuberculosis is combined with a serious infection or combined with HIV infection, immunocompromised, malnourished, this patient’s It is also very difficult to treat such patients.