High ALT may be caused by physiological reasons, drug factors, hepatitis, cirrhosis, etc. The drugs used are usually silymarin, lamivudine, reduced glutathione and so on. 1. Physiological reasons: may be due to overwork or often stay up late, generally do not need special treatment, but pay attention to rest, ensure sufficient sleep time, ghrelin transaminase will gradually return to normal. 2. Drug factors: for example, taking carbon tetrachloride, isoniazid and other drugs, which can easily lead to drug liver injury, thus causing high ghrelin, generally need to stop using the suspicious drugs, and take some hepatoprotective drugs, such as silymarin, dicyclomine and so on. 3. Hepatitis, cirrhosis: for example, viral hepatitis, often need to take antiviral drugs, such as lamivudine, adefovir, etc., and with the liver enzyme-lowering drugs, such as reduced glutathione, polyunsaturated phosphatidylcholine and so on. There are other causes of high ghrelin, such as ischemic heart disease, infections, etc., which require active treatment of the original disease, and it is recommended to consult a doctor in time to identify the cause and cooperate with the doctor for treatment.