The injection is not always necessary for precocious puberty in girls, but usually needs to be injected for about one year, the specific injection time is related to the severity of the child’s condition and the recovery of the disease. The treatment of precocious puberty, if belongs to the central precocious puberty only need to receive inhibitory hormone drugs injections, such as leuprolide and buserelin, the specific treatment time is related to the severity of precocious puberty in children and the results of the treatment, most of the children need to be about a year. Adverse effects of buserelin include nausea, vomiting, fever, headache, and decreased libido, and contraindications to its use have not been defined; those of leuprolide include nausea, vomiting, anemia, and loss of appetite, and it is contraindicated in women during pregnancy, gestation, and lactation. In addition, the application of the above drugs have certain risks, patients should be used under the guidance of a doctor.